Monday, December 23, 2019

Unit 40, Dementia Care Essay - 2376 Words

Dementia is a progressive disorder that will affect how you’re brain functions and particularly your ability to remember, think and reason. Dementia usually affects older people and are approximately 820,000 people in the UK with the disorder, and around 15,000 are under the age of 65. If the dementia is recognised early enough that are a lot of things that you can be done to make the quality of life better. In a lot of dementia cases the symptoms and quality of life will progress and get worse over a number of years. The most common symptoms of a dementia patient are: * Forgetfulness, maybe forgetting names of people that you have been in contact with every day, or forgetting what you did just hours or days ago. * Having†¦show more content†¦Some effects may be that they may not remember things that they have done days ago but they may clearly remember things such as World War Two. This may have an effect on a person’s self esteem as they will be noticing the change in their behaviour and memory and it will make them think about what has changed and because of their short memory they may get worried that something bad has happened to them but they cannot remember. It can also effect self esteem and a person’s confidence because if they lose the ability to communicate and understand what people are saying to them they may shut down and just ignore everyone that they come into contact with as they may feel embarrassed about their lack of communication. Alzheimer’s disease can have a big effect on family members around the person with the disease; it would be upsetting seeing a loved one got through such a major change in their behaviour and their mental capability. If you live with someone with Alzheimer’s and they are wondering in the middle of the night and have sleep difficulties and this can disturb the family in the house. Also if they are wondering around in the middle of the night around the community the police may pick them up, meaning they are again disturbed as the police will need to contact someone to make sure that the person is ok. There are also worries about financial problems that the Alzheimer’s sufferer may have, if they cannot manageShow MoreRelatedEssay on Unit 4222-237 Dementia awareness720 Words   |  3 PagesUnit 4222-237 Dementia awareness (DEM 201) 1.1 Dementia is a loss of brain function. If affects memory, thinking, language, judgement and behaviour. Dementia is progressive, so the symptoms will gradually get worse. 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The Mind Adults age 65 years and older makeRead MorePatients Health Of Medical Marijuana1733 Words   |  7 Pageswill look at the improvements in meal consumption, Clinical Global Impression scores, Pittsburgh Agitation Scale, and the decrease in the symptom being monitored. The studies being reviewed research many conditions ranging from Alzheimer disease, dementia patients, dystonia, dyskinesias, and tics, and pain management. Many studies indicate that the results may vary, and the extent of its beneficial properties should be determined by the patients’ physician. It is hypothesized that the patients thatRead MoreDementia Essay3997 Words   |  16 Pagesï » ¿Unit 4222-237 SADIE LEWIS Outcome 1 1.1 Dementia is the progressive decline in the cognitive function, involving all aspects of perception, thinking, reasoning and remembering. This is largely to do with damage or disease. This is progressive and leads to the deterioration of the mind, affecting an individual’s ability to concentrate on daily tasks. The memory is often affected, causing them to forget people, dates and events that are recent to them, behaviour can be erratic

Sunday, December 15, 2019

Intercultural Business †Drug Tests in India Free Essays

string(98) " could be more difficult to find an easy solution but it might be more suitable for both parties\." Case Study Intercultural Business im Studiengang B. A. International Management Thema: Drug tests in India IContents IContentsII IIList of figuresIII IIIList of abbreviationsIV 1Essential moral standards and norms1 2The practical value of economic ethics concepts3 3The RADAR concept5 4Business activity in India8 5Comparison of the cultures9 6Preperation for the NGO meeting14 IV. We will write a custom essay sample on Intercultural Business – Drug Tests in India or any similar topic only for you Order Now BibliographyV Declaration IIList of figures Figure 1:Overview of the different business ethics concepts3 Figure 2:Points of the RADAR concept5 Figure 3:Comparison of the differen cultural dimensions9 ? IVList of abbreviations BVVB AGBacteria and Virus Vaccine Biotechnology CRE Ltd. Clinical Researche Enterprise Limited NGONon-Governmental Organisation WMAWorld Medical Association PDIPower Distance IDVIndividualism vs. Collectivism MASMasculinity vs. Femininity UAIUncertainty Avoidance LTOLong-Term Orientation CfConfer ? 1Essential moral standards and norms â€Å"Humans are more moral than they think and far more immoral than they can imag-ine. † Sigmund Freud In general moral standards and norms are always based on a culture. Every culture has got its own definition of morality and ethics. Morality can be defined as the standards that an individual or group has got about what is right and wrong, or good and evil. The pharma industry itself includes some essential moral standards and norms on na-tional and international base. First it is necessary to prove moral standards and norms on a global level. The â€Å"Declara-tion of Helsinki† developed by the World Medical Association (WMA) is: â€Å"a statement of ethical principles for medical research involving human subjects, including research on identifiable human material and data. Furthermore this declaration gives essential moral standards and norms according to the pharmaceutical branch, e. g. â€Å"In medical research involving human subjects, the well-being of the individual research subject must take precedence over all other interests. † The second part is the national moral standards. In Germany the ethical standards refer to the principle: â€Å"The health is the highest property of a human bein g. † These standards are set by statue from the â€Å"Zentrale Ethikkommission†. Furthermore German companies always have to obey the German law. The American ethical standards are saying the same in the â€Å"Declaration of Professional Responsibility: Medicine’s Social Contract with Humanity. † from the American Medical Association, e. g. â€Å"Respect human life and the dignity of every individual† The focused standards above exist also in India. They are formed by the Indian Council of medical research. All standards point out what the ultimate principle of medical researches is. : All medical tests shall focus on health and care of every human being. â€Å"Act as if the maxim of your action were to become through your will a universal law of nature. Immanuel Kant by Serafini (1989) The definition of moral standards and norms above should be based on deontological ethics. It says that the background and the consequences or effects that an action takes is irrelevant – only the action itself matters. Roughly speaking, deontologists hold that some choices cannot be justified by their effects, no m atter how morally good their con-sequences are. Therefore some choices are morally forbidden. But in reference to the drug tests the moral standards are based on the teleological theo-ry. The teleology is characterized primarily by a focus on the consequences which any action might have. That means if an action (drug tests) might be incorrect, but the con-sequence (effective medicine) is correct and helpful, then it is morally correct. Today we are encouraged to act on the base of different ethical frameworks before we are able to make a clear decision about the ethical correctness of our intended actions. The codes of conduct, which are the ethical guidelines are based on those frameworks. 2The practical value of economic ethics concepts The following discussion deals with the four different economic ethics concepts and their practical values. They are defining how to combine ethics and profit in different ways and with their consequences. Figure 1 The different business ethics concepts Firstly there is the functional business ethics concept. If a company act in agreement with certain known rules and under specific ethical conditions it is allowed to gain the maximum profit. â€Å"Ethic† is a â€Å"factor or rentability† or a â€Å"critical factor of success†. That means: The â€Å"investment† in â€Å"ethics† in terms of acceptance of current opportunity costs has its foundation in the strategic aim to save long-term profit chances. This concept is not used by the BVVB AG, because they are not acting under specific ethical conditions. The second concept to focus is the corrective Business ethics concept which implements ethical standards into the daily business. That means companies are acting in their nor-mal economic way but ethics standards always have the priority over profit gaining ac-tions. It is a voluntarily self-limitation of profit maximisation. For the BVVB AG only the profit gaining process matters. The integrative Business ethic is the permanent process of critical reflexion of business activities. Every possible profit and business success should get the legitimisation of all stakeholders. The consequence is that the company might have to abdicate a profit chance. The action of the BVVB AG shows that they are not acting in reference to what the stakeholders defining as the best way. The last concept is the charitable Business ethic concept. The priority is to gain the maximum profit and afterwards the company starts to donate a part of the money for charitable aims. The morality of a business action does not matter anyway. Due to the descriptions of the different concepts it is clear that the BVVB AG should act based on the charitable business ethics concept. In the current situation it is the highest priority to gain profit and to be successful (=gain the maximum profit). But after having success the BVVB AG should use a part of the gained money to serve non-economical claims. The practical value of the concept is the possibility to define an eth-ical business aim and the commitment to act in a moral and ethical way. 3RADAR concept The RADAR concept serves to take a decision with the comprehension of ethics. In consideration of ethics in the factoring process it could be more difficult to find an easy solution but it might be more suitable for both parties. You read "Intercultural Business – Drug Tests in India" in category "Papers" In the following paragraph the steps 1 to 10 of the RADAR concept, as seen in the fol-lowing image, will be analysed and discussed. Figure 2: Structure and Points of the RADAR concept Recognize Step 1 Determine if there is an ethical component The component is the drug tests in India. The accomplishment of these tests is not un-morally – it is important – but the way the tests will be carried out is morally questiona-ble. The BVVB AG could hold the tests in Europe or the USA but due to finical prob-lems and the necessity of the reduction of costs the tests will be done in a financially weak area in an Indian hospital. Furthermore the BVVB AG does not know if the health of the patient will be always protected. Step 2Check the ethicalness of the ethical omponent against ethical standards For my own values the conditions under which the tests are carried out are not morally and direct against my ethical values. For the BVVB AG it depends on two points. On the one hand India is the cheapest choice for the realization of the test process and on the other hand the company is not acting illegal but the aim is to develop a new effective medicine against illn esses and to test the agent, subjects are needed. On the basis of the Global Business Standard Codex (GBSC) it is absolutely unmorally. The codex considers the point â€Å"Human Dignity†, which requires the protection of hu-man health and the respect of fundamental human rights. Step 3Conclusion In consideration of the mentioned aspects above the implementation of the tests in India is not illegal but they fulfil not the ethical and moral standards. Assess Step 4Who are the key stakeholders? The main stakeholders of the BVVB AG and the new vaccine are primary the internal stakeholders, especially the managers and employees. Because of the financial situation the members of the BVVB AG are reliant on the success of the tests. The external stakeholders are the subjects, without their help the tests cannot be carried out. Step5What ethical standards apply? The CRE Ltd. and the BVVB AG carry responsibility to inform the respondent about the possible side effects and the probability of their appearance. Furthermore the com-pany is responsible to take care about the state of the subjects’ health. In turn of these duties the subjects have the right to be treated with fairness and dignity. Step 6 How is the proposed action likely to impact them from an e. g. economic and ethical view? The positive long- and short-term effects are that the habitants from India, especially the majority of people from slums, have never had contact to medical treatments or a simple medical examination. For the people who are part of the tests it could lead to the healing of diseases. Contrariwise there also exist some negative effects in a short-term period – the side ef-fects. The subjects could get negative side effects from the vaccine. But the laboratory has figured out medical therapies to heal the serious side effects either by a special treatment or through hospital stay. Step 7See if there is a specification and quantification of the positive and negative con-sequences which could result from the intended action. The performing of the tests in India could result in bad or negative reputation. Too much bad reputation could result in a damage of the company’s image and could end up in the loss of clients and creditors. This would indicate that the BVVB AG takes a financial risk. Step 8What could be done to reduce the likelihood of or at least reduce the negative impact? Due to the necessity of the tests the company has to ensure the reduction of negative reports. To avoid them the only way is to guarantee better circumstances of the tests and the security and wellbeing of the subjects. Furthermore the company could assure that India receives some medicine for free to help infected people after a successful conclu-sion of the test series. Decide Step 9 Take a decision The BVVB AG in connection to the CRE Ltd. has to carry out the tests in India, be-cause of the financial situation. To some people it may create the impression of being â€Å"bad† but the real aim something positive one. The vaccine could help millions of people and also Indians. To reduce the negative aspects the tests have to be carried out under better conditions, considering a higher care for the subjects’ health. Step 10 Correct for self-serving biases If I am asked if I want to read about that in the newspaper I would say â€Å"Yes† because reaching better conditions and to ensure the responsible manners with the tests and the well-being of the persons is positive and could have an effect on the image and make other companies to think about their actions. ? 4Business activity in India This paragraph defines some essential facts about cultural conventions in India. To have success on business in India, in my opinion, the first priority is to be familiar with the cultural conventions because the opinion about business differs a lot between Indians and Europeans. The distinctions may lead to misapprehensions. To be accepted and to show respect it is necessary to learn some basic modes of behaviour and funda-mental cultural differences. It could be helpful to learn some basic phrases of the Indian language for having a small-talk but it is not that important to speak perfectly because the Indians speak over 500 dialects e. . people from the north often talks to someone from the south in English. Furthermore it is good to know that Indians never say â€Å"No† because it is impolite to negate something. It is common to say â€Å"I will try it†. Generally it is important to keep in mind that a personal and polite contact between people from every age is ensured. Indians set a high value on trustworthiness. The first contact could be a h andshake but it is common to give a friendly nod. Shaking the head does not mean â€Å"No† it is a gesture of attentive listening. Also the way of dressing is important. Women may never show skin, like naked legs or shoulders. Men are allowed to wear shorter clothes if it is hot outside but it has to be suitable for business. Indians are very hospitable. It is common to get or to make an invitation for dinner. Due to the different persuasion there are some different rule for preparation and consump-tion. But it exists a general rule: â€Å"Peel it, boil it, or forget it. † ? 5Comparison of the cultures The following paragraph deals with the different cultures of Germany, India and USA. The distinctions between the different nations and cultures will be discussed and ex-plained with the help and use of the cultural dimensions of Geert Hofstede. Professor Geert Hofstede conducted one of the most comprehensive studies of how values in the workplace are influenced by culture. Figure 3: The different cultural dimensions in comparison of their characteristics source: geert-hofstede. com The 1st dimension – The Power Distance (PDI) Power distance is defined as: â€Å"The degree to which the less powerful members of a so-ciety accept and expect that power is distributed unequally. The undamental issue here is how a society handles inequalities among people. People in societies exhibiting a large degree of power distance accept a hierarchical order in which everybody has a place and which needs no further justification. In societies with low power distance, people strive to equalize the distribution of power and demand justification for inequalities of power. † The comparison of the cultures in the diagram shows that there is a high difference be-tween the USA, Germany and India. The low score of Germany (35) and the USA (40) in this dimension shows clearly the general proposition of â€Å"liberty and justice for all†. It is common that both managers and employees expect to be engaged and information is shared frequently. Also both cul-tures have in common that the communication style is direct, informal and participative. Furthermore in both cultures there is no strict hierarchical order established. But in India on the contrary there is a relatively high power distance (77). The hierarchical structure is hard in organizations as well as in society. Also the real power of managers and control is high and accepted. The communication style differs totally from the western and European style. Someone would never be criticized if there is a 3rd person in the room and the communication is top – down. In contrast to Germany and the USA, where also an employee may criticize a manager, in India an employee would never give negative feedback to someone who is up the ladder 2nd dimension – Individualism versus Collectivism (IDV) Individualism, the high side of this dimension, can be defined as: â€Å"A preference for a loosely-knit social framework in which individuals are expected to take care of them-selves and their immediate families only. And collectivism, the low side of this dimension, can be defined as: â€Å"A representation of a preference for a tightly-knit framework in society in which individuals can expect their relatives or members of a particular in-group to look after them in exchange for unquestioning loyalty. † A society’s position on this dimension is reflected in whether people’s self-image is de-fined in terms of â€Å"I † or â€Å"we. † As seen in the 5-D-Modell, all three countries and their cultures have different levels of this dimension. The USA, with a score of 91 is highly individualistic. That means it is common that people in general first look and take care for themselves and their families. The Ameri-cans are mostly doing business with strangers and employees are expected to be self-consistent. Germany scored 67 – truly individualistic. In comparison to the USA the bigger family means a lot to the Germans, especially the parent-children relationship. Loyalty, duty and responsibility are common. In business it is common to give someone an advice if there was a mistake to give him the chance to learn from it – â€Å"Be honest, even if it hurts†. In contrast to Germany and the USA India is clear collectivistic with a score of 48. To Indians it means a lot what the social framework is thinking about an action and they are asking for advice. Also in business everything starts with a personal relationship, especially hiring and promotion. 3rd dimension – Masculinity versus femininity (MAS) This dimension is defined as: â€Å"The masculinity side of this dimension represents a pref-erence in society for achievement, heroism, assertiveness and material reward for suc-cess. Society at large is more competitive. Its opposite, femininity, stands for a prefer-ence for cooperation, modesty, caring for the weak and quality of life. Society at large is more consensus-oriented. â€Å" The fundamental issue here is what motivates people, wanting to be the best (masculine) or liking what you do (feminine). All three cultures are considered a â€Å"masculine† society (scores 56 – 66). Children learn from the early times on that performance is highly valued and the people â€Å"live in order to work†. It is also relevant to be authorial, assertive and decisive. Their behavior stands under the conditions â€Å"strive to be the best they can be. and worldwide known sentence: â€Å"the winner takes it all! † All cultures love to show their success through material objects. For Indians â€Å"work is the center of life† and the workplace serves as symbol of success. 4th dimension – The Uncertainty avoidance (UAI) The uncertainty avoidance dimension expresses: â⠂¬Å"The degree to which the members of a society feel uncomfortable with uncertainty and ambiguity. The fundamental issue here is how a society deals with the fact that the future can never be known: should we try to control the future or just let it happen? Countries exhibiting strong UAI maintain rigid codes of belief and behavior and are intolerant of unorthodox behavior and ideas. Weak UAI societies maintain a more relaxed attitude in which practice counts more than prin-ciples. † Concerning the Uncertainty avoidance the cultures have differences. Americans accept new ideas and innovations. They are more tolerant of ideas or opinions from anyone and allow the freedom of expression. Indians also have a lower preference for avoiding un-certainty. They have a high acceptance of imperfection and do not follow strict rules. Indians say: â€Å"nothing is impossible†, as long as one knows how to â€Å"adjust†. In comparison Germany scored high (65) and they follow deductive methods. For Germans it is important to have a plan. Every action has to be systematically and de-tailed planned. Germans prefer to compensate for their higher uncertainty by strongly relying on expertise. 5th dimension – Long-term orientation (LTO) â€Å"The long-term orientation dimension can be interpreted as dealing with society’s search for virtue. Societies with a short-term orientation generally have a strong concern with establishing the absolute Truth. They are normative in their thinking. They exhibit great respect for traditions, a relatively small propensity to save for the future, and a focus on achieving quick results. In societies with a long-term orientation, people believe that truth depends very much on situation, context and time. They show an ability to adapt traditions to changed conditions, a strong propensity to save and invest thriftiness, and perseverance in achieving results. † America and Germany have a relatively low score in this dimension. That means they are more short-term oriented. In business people strive for quick results and a strong concern with establishing the truth. The Indians in contras have a long-term orientation, time and punctuality does not matter and they never follow the exact plan, if there is a plan existing. ? 6Preperation for the NGO meeting â€Å"Morality is temporary, wisdom is permanent. † Hunter S. Thompson For the meeting with the NGO? s in India it is necessary to know what they are criticiz-ing on the project. They are criticising that the BVVB AG is exploiting the Indian popu-lation due to the tests in India. The need of that meeting is to convince the members of the NGO about the necessity and benevolence of these tests. It is obvious that the BVVB AG in cooperation with the CRE Ltd. is doing the tests in India in order to eco-nomic and financial reasons. But due to the extensive economies it could also be beneficial for India, especially if the BVVB AG decides to act on the charitable business concept. The non-attendance of tick-bourne in India does not matter for testing the medicine. The danger to contract an infection is small and there is also existing medicine and plans how to heal the people in case of an infection. Furthermore it is of a high importance to know everything about the negative media reports. To convince the NGO about the tests it would be helpful to adjust with the BVVB AG management if it could be possible to donate a certain contingent of the profit and also to donate a certain percentage of the vaccine to India to combat the leprosy virus. Furthermore it could be helpful to assure that the CRE Ltd. will care for good circum-stances. The subjects will get a good treatment and the welfare will be ensured. Due to the fact that Panjaa is a Non-Governmental-Organization it would be not effec-tive trying to bribe the organization with money. It would be more effectively to show them the good sides of the tests for the Indian nation. ? 1. Bibliography Literature FREUD, Sigmund (1930), â€Å"Civilisations and its Discontents† KANT, Immanuel, â€Å"Good Will, Duty, and the Categorical Imperative,† ed. Anthony Serafini, Ethics and Social Concern (1989) (New York: Paragon House Publishers) LIPPER RASMUSSEN, Kaspar (2005) „Deontology, Responsibility and Equalityâ€Å" SALZMANN, Todd A. 1995), „Deontology and Teleologyâ€Å" ULRICH, Peter (2008), „Integrative Business Ethics: Foundation of a Civilized Market Econo-my† ULRICH, Peter (1997), â€Å"Integrative Wirtschaftsethik – Grundlagen einer lebensdienlichen Okonomie† Web research Homepage from the World Medical Association: â€Å"The Declaration of Helsinki†. URL: www. wma. net/en/30 publications/10policies/b3/ (last downloaded 09. 11. 12) Homepage from the Freiwillige Selbstkontrolle fur die Arzneimittelindustrie e. V. , „Verhal-tenskodexâ€Å", URL: http://www. fs-arzneimittelindustrie. e/verhaltenskodex/ivd/ (last downloaded 14/11/2012) Statement from the Arbeitskreis Medizinischer Ethik-Kommission, „Stellungnahme zum Vor-schlag fur eine Verordnung des Europaischen Parlaments und des Rates uber klinische Pru-fungen mit Humanarzneimitteln und zur Aufhebung der Richtlinie 2001/20/EGâ€Å" URL: http://www. ak-med-ethik-komm. de/documents/StellungnahmeEUVerordnungklinischePruefungen. pdf (last down-loaded14/11/2012) Hompage from the American Medical Association, „Declaration of Professional Responsibil-ity†, URL: http://www. ama-assn. rg/ama/pub/physician-resources/medical-ethics/declaration-professional-responsibility. page? (last downloaded 14/11/2012) Homepage from the Zentrale Ethikkommission bei der Bundesarztekammer, „Priorit aten in der medizinischen Versorgung im System der Gesetzlichen Krankenversicherung (GKV): Mussen und konnen wir uns entscheiden? â€Å" (2000), URL: http://www. zentrale-ethikkommission. de/page. asp? his=0. 1. 24 (last downloaded 14/11/2012) Published paper by the Indian Council of Medical Research, â€Å"Ethical Guidelines for biomedi-cal research on human participants†, (2006), URL: http://icmr. ic. in/ethical_guidelines. pdf (last downloaded 14/11/2012) Homepage from Handelsblatt, FRANK, Sergey „Die indische Kultur besser verstehenâ€Å", (2009) URL: www. handelsblatt. com/unternehmen/management/strategie/weltspitze-die-indische-kultur-besser-verstehen/3304528. html (last downloaded 10. 11. 2012) Homepage from Geert Hofstede, URL: geert-hofstede. com (last downloaded 12/11/2012) http://www. goodreads. com/quotes/178430-morality-is-temporary-wisdom-is-permanent (last downloaded 12/11/2012) How to cite Intercultural Business – Drug Tests in India, Papers

Saturday, December 7, 2019

Construction, Design and Analysis of a Single

Construction, Design and Analysis of a Single-lesi Essay on Containing Shuttle Vector for Use in Studies of Transcription-coupled DNA Repair This summer, I have had the incredible opportunity of working with ___ under the direct mentorship of ___ on designing, constructing and analyzing a single-lesion containing shuttle vector to be used for studies of transcription-coupled DNA repair (TCR). This experience has provided me with insight into the logic behind genetic engineering and experiment design and given me greater aptitude in various laboratory procedures including RT-PCR (reverse transcriptase polymerase chain reaction), plasmid transfection and recovery, plasmid transformation and amplification, and RNA isolation. It was the creativity of the design-associated aspects of our project that I found most satiating. In fact, in order to keep up with the evolution of the construction design, I learneda good deal of interesting biology that I now find the most valuable aspect of my internship. Enthusiastic about the knowledge I have gained while spending my days at the Cooper lab, I feel compelled to write this web-page with a focus that emphasizes the progression of my understanding about TCR and single-lesion containing shuttle vectors while it describes the experiments and protocol optimizations I performed. AbstractOur goal is to design a shuttle vector that contains a unique, site-specific lesion in order to study transcription-coupled repair of human DNA. In our system, the lesion is introduced by insertion of a synthesized 8-oxoguanine-containing oligomer into a pS189-derived plasmid at either of two locations: within the t-antigen (Tag) intron 400 bases beyond the ATG translation start codon, or at the end of the Tag, after the polyadenylation signal. The pS189 shuttle vector was modified to increase the transcription frequency of the Tag, prevent plasmid replication, and distinguish between Tag derived from SV40-transformed cells and that from the shuttle vector. Initial studies were undertaken to optimize the transfection conditions and also to verify the various plasmid alterations. Preliminary RT-PCR of mRNA harvested 24 hours after plasmid transfection has demonstrated that use of primers tuned to the Tag modifications do successfully distinguish plasmid from cellular RNA. Replication assays using methylation-sensitive endonucleases have verified the competence of engineered mutations in the SV40 ori in achieving preclusion of plasmid replication. RT-PCR has also shown low amplification near the Bgl II site, suggesting its removal during the processing of mature mRNA. It will therefore be necessary to construct a new site for lesion insertion before the poly-adenylation signal. In conclusion, with the competency of the pS189-derived plasmids confirmed by RT-PCR, both the shuttle vector and the transfection protocol have been optimized for TCR studies, and we are ready to insert the 8-oxoG-containing oligomer. IntroductionToward maintenance of genomic integrity and to combat the mutations and genetic degradation associated with aging and cancer, several intricate and interconnected pathways exist for DNA repair. These repair pathways include nucleotide excision repair (NER) and base excision repair (BER). Excision and repair of lesions on the transcribed strand (TS) occurs at a higher frequency than on the non-transcribed strand (NTS). This phenomenon called transcription-coupled repair (TCR) seems to be initiated by RNA polymerase II stalled at lesions or lesion-protein complexes. Lesions introduced by reactive oxygen species generated during cellular metabolism, including 8-oxoguanine (8-oxoG), are subject to TCR, even though they do not impede DNA polymerase during replication. If left unrepaired, 8-oxoG lesions can mispair with adenine and, upon replication, cause a guanine to thymine transversion with 50% frequency. Impedance of TCR results in a degenerative disease, Cockayne Syndrome (CS), characterized by postnatal developmental failure, neurological degeneration and early death. Another disease, Xeroderma Pigmentosum (XP), involves the global malfunction of nucleotide-excision repair (NER) due to mutations in the XPA-XPG proteins. Previously, investigators introduced oxidative lesions in a random, stochastic manner, making the detailed kinetics of TCR difficult to assay. .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .postImageUrl , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .centered-text-area { min-height: 80px; position: relative; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:hover , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:visited , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:active { border:0!important; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .clearfix:after { content: ""; display: table; clear: both; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:active , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .centered-text-area { width: 100%; position: relative ; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:hover .ctaButton { background-color: #34495E!important; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .u4ec2d6ecb734c6d9b46b4d2362d6dfd5-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:after { content: ""; display: block; clear: both; } READ: Frees: Black Success through Hard Work or Af Essay These limitations can be surpassed with the constructing of site-specific single-lesion containing shuttle vectors. Our Research GoalsTo study transcription-coupled repair of oxidative damage to DNA in various cell lines from Cockayne Syndrome (CS) and Xeroderma Pigmentosum (XP) patients, using a single-lesion containing shuttle vector. To further characterize both the requirements for XPD/XPB/XPG in TCR, and the behavior of RNA Polymerase near oxidative lesions. To further assess the degree to which lesions caused by oxidative damage (specifically

Saturday, November 30, 2019

Intern report free essay sample

The Central Bureau of Investigation (CB) is the premier investigating police agency in India, and is an elite force which plays a major role in the preservation of values in public life and ensuring the health of national economy. It is a governmental agency under Government of India It was only after the SC decided to monitor its the CB moved faster and arrests of high-profile persons were made. GAG who audits all receipts and expenditure of the Government of India and the state governments, including those of bodies and authorities substantially financed by the overspent.The GAG is also the external auditor of government-owned companies,.. A GAG report on issue of Licenses and Allocation of 26 Spectrum resulted in a huge controversy. The report estimated that there was a presumptive loss of 1,766. 45 billion (US$30 In a chariest filed on 2 April 2011 by the investigating agency Central Bureau of Investigation (CB), the agency pegged the loss at 309,845. We will write a custom essay sample on Intern report or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page 5 million (US$5. It has the status of an autonomous body, free of control from any executive authority, harmed with monitoring all vigilance activity under the Central Government of India, and advising various authorities in central Government organizations In planning, executing, reviewing and reforming their vigilance work.

Monday, November 25, 2019

Brothels and Convents During the Renaissance essays

Brothels and Convents During the Renaissance essays In this essay, I will focus mostly on the regulation of both convents and brothels in the time of Shakespeare and the Renaissance. Ruth Mazo Karras, The Regulation of Brothels in Later Medieval England, focuses exactly on this topic throughout England and other European countries during the Renaissance. In regards to the convents I will be looking closely at an article entitled Subjects on the World's Stage: Essays on British Literature of the Middle Ages and the Renaissance, written by David G. Allen and Robert A. White. The regulations of brothels during the Renaissance were regarded heavily. Karras says that women within these brothels were basically regarded as evil and as sinners yet they remained occupying the position of prostitution solely because of the sexual appetites of men; these brothels were considered a necessary evil(Karras). The first parallel between women of convents and stews is the aspect of being forbidden from being a part of every day society. Women who lived in convents were completely shut off from the public - no insiders could leave and no outsiders could come in (Allen). The only difference in the secrecy of these two places was the fact that brothels were visited by men. Karras also states that the women of brothels were not given the rights of "regular" women. In some places, she was not allowed to reject any customer, indeed could not be raped because she was considered to belong to all men and thus had no right to withhold consent (Karras). These two aspects of womens lives in this time period play a major part in the drama "Measure for Measure", and especially set up the scene in the opening act of the play. When Claudio sends for his sister, Isabel, to help him get out of jail, in which he was sentenced to death for having premarital (by the eyes of the church) sex with Juliet, Isabel leaves the convent in which she was about to t...

Friday, November 22, 2019

Assignment of Applied Linguistics

Teaching is that profession where the success of the teachers depends on the ability of the students. As we know that every good teacher knows that all students do not learn in the same way every student learns at different speed and reacts differently. So, teacher should be focused on, that every student gets a chance to learn and for that, teacher should be creative in using different kinds of teaching method. They have to choose a suitable method to convey the knowledge because they will find different situation and different students in the class. Generally, students would not be able to believe that they could be successful in learning language. This lack of motivation has made students do not have confidence to speak in the target language because they do not want to make any mistake. Moreover, they find difficulties to recollect the previous lesson, such us memorizing the new vocabularies. This situation encourages teacher to be creative and to use an effective method on teaching. In addition, students have different type of learning style. They learn through their own learning styles which are visual, auditory style. Those who are visual learn trough seeing and they need to see the teacher’s body language and learn best from visual displays. Then, those who are auditory learn through listening and they learn best through verbal lectures, discussions, talking things through, and listening to what others have to say Teacher should choose appropriate method of teaching different for types of students, to motivate students, and to increase students memorizing ability. Suggestopedia and Silent Way is one of those methods that can be used by teachers. Silent Way Method: The Silent Way is the name of a method of language teaching devised by Caleb Gattegno. The very name Silent Way highlights the fact that it is based on the idea that the teacher should be silent as much as possible in the classroom but the learner should be encouraged to produce as much language as possible. To let the teacher concentrate on what the students say and how they are saying it, drawing their attention to the differences in pronunciation and the flow of words. The significance of this method is that the learner eventually discovers what ability he has, which he has not yet had an opportunity to discover. The three basic tenets of the approach are Learning make possible if the learner discover rather than remembers or repeats In it the teacher and the learner work cooperatively to reach the educational desired goals. The learner is not a bench bound listener but an active contributor to the learning process. Learning is helped by physical objects The Silent Way uses colorful charts and rods (cuisinere rods) which are of varying length. They are used to introduce vocabulary (colors, numbers, adjectives, verbs) and syntax (tense, comparatives, plurals, word order). For example: teacher has introduced the idea of pronouns as in â€Å"Give me a green rod†. The class will then use this structure until it is clearly absorbed, using all the other colors. One member of the class would now like to ask another to pass a rod to a third student but she does not know the word â€Å"her†, only that it cannot be â€Å"me†. At this point the teacher would interfere and supply the new item: â€Å"Give her the green rod† and the learner will continue until the next new item is needed (probably â€Å"him†). Problem-solving is central to learning. This can be summarized by Benjamin Franklin’s words: Tell me and I forget Teach me and I remember Involve me and I learn† A good silent way learner is a good problem solver. The teacher’s role exist in only in giving minimum repetitions and correction, remaining silent most of the times, leaving the learner struggling to solve problems about the language and get a grasp of its mechanism. Suggestopedia Method: The term Suggestopedia, derived from suggestion and pedagogy. This term is developed in the 1970’s by Bulgarian psychologist and educator, George Lazanov. Suggestopedia is a teaching method which is based on a modern nderstanding of how the human brain works and how we learn most effectively. Lazanov argued that learners have difficulties in acquiring English as the second language because they do no want to make any mistake. When the learners are in this situation, their heart and blood pressure raise. He believes that there is a mental block in the learners’ brain. This filter blocks the input, so the learners have difficulties to acquire language caused by their fear. Music was central to his method. Music helps the students to reach a certain state of relaxation, in which the interest is increased. Moreover, it involves emotional meaning in given the lesson which help students better in memorizing. There are two types of suggestions first one is direct and second is indirect suggestion. The students learn English not only from direct instruction but also from indirect instruction. DIRECT: Direct suggestions are directed to conscious processes i. e. orally by the teacher, and/or by text materials. INDIRECT: Indirect suggestion is largely unconsciously perceived. In the teaching learning process, students who make mistakes are tolerated, for example in pronouncing the word. The stress is on the content not the structure. Grammar and vocabularies are presented and given treatment from the teachers, but not dwelt on. Homework is limited in this method Techniques: Suggestopedia: Classroom set-up, that is, the teacher provides as peaceful and relaxed an environment as possible. The classroom is provided with dim lights, soft music; soften armchairs, and walls decorated in order to make the students’ mind more relaxed. Silent Way In the class, the teacher uses rods which consist of ten brightly colored wooden blocks of different length, a word chart, a phonic chart, drawings, Worksheets and books. Colored charts are used in the first phase a practice pronouncing sounds and then the rods are used to practice saying words and numerals in the second phase. In the third phase, the rods are used to practice speaking. The teacher says as few words as possible, but uses more gesture and charts. The constant visual exposure to these rods and charts is the vital part of the techniques. The principle of the methods is that teaching should be subordinate to learning and the teacher’s role is to help the students to acquire the language more than just learning it. Advantages and Disadvantages of suggestopedia: -The first advantage of using suggestopedia for teaching English is that suggestopedia method use music during the process of learning. 2-The second advantage of using suggestopedia methods in teaching English is that suggestopedia methods have different class setting which make the students relax during the learning process. 3- Suggestopedia methods also decorate the class with posters or something which can make students’ mind relax, such as by putting flowers or aquarium in the corner of the class. By using poster, the students will always learn even when they just look around the classroom. -Beside the advantage, using music during the learning process also has disadvantages for some people who cannot study in the noisy class, it is difficult for them to divide their mind into two sides, to the music and to the lesson. 5-Another disadvantage is that suggestopedia method will be difficult to be practiced in the development country such as Indonesia. As we know that in Indonesia there are at least 30 – 40 students who fill in the one class. The teacher will be difficult to control them one by one. In conclusion, there are some advantages and disadvantages of using suggestopedia methods. As a good teacher we have to know what methods that appropriate for our students. Therefore before we choose a teaching method we have to consider its advantages and disadvantages. Suggestopedia is a good method for teaching, because the memorization can be done 25 times faster than the conventional method. But, there are also disadvantages of using it. So, we should be wise when we have to choose the method that we will use for our students. Advantages and Disadvantages of silent way: 1-This method foster cooperative learning between individuals. -It embodies a new approach to education in general, a respect for the individual and an awareness of the individual’s extraordinary cognitive powers. 3-This method can be benefited by the teacher only in small groups of students. The teacher can gain ability in this method by trying. The teacher is expected to enhance the materials on his/her own. 4-For some teachers the strictness of the system (no repetitions by the teacher, no an swers by the teacher etc. ) may be meaningless. 5-Language is separated from its social context and taught through artificial situations usually by rods. -How such a method would in the average classroom situation or how successfully it might be used at more advanced levels is a question mark left in our minds. 7- It would seem necessary for a teacher to gain a good deal of training and skill in order to apply the Silent Way to the teaching of a total grammar in all its complexity, if such a broad application is, in fact, possible 8-The Silent Way is often criticized of being a harsh method. The learner works in isolation and communication is lacking badly in a Silent Way classroom. 9-With minimum help on the part of the teacher, the Silent Way method may put the learning itself at risk. 0-The material (the rods and the charts) used in this method will certainly fail to introduce all aspects of language. Other materials will have to be introduced. Principles and Characteristic of silent way: 1. Errors: Are indispensable and natural part of the learning process. Self-correction and peer-correction are emphasized. The teacher corrects the language only as a last resort. 2. Repetition: Consumes time and encourages the scattered mind to remain scattered. If the teacher avoids repetition strictly, this will force alertness and concentration on the part of the learners. By this way the efficiency in learning will be increased and the time will be saved for further learning. This principle is against ALM. 3. Students native language: Native language can be used to give instructions when necessary. Also native language can be used during the feedback sessions (at least for beginner levels). If the native language is not very essential then it is avoided. 4. Evaluation: Although the teacher does not have to give a formal test, s/he assesses student learning all the time. One criterion of whether or not students have learned is their ability to transfer what they have been studying to new contexts. The principles of suggestopedia: 1. The first principle is that people are able to learn at rates many times greater that what we commonly assume to be limits of human performance. 2. The second principle is that learning is global; it involves the entire person. 3. The third principle is that people learn either consciously or unconsciously or both, either rationally or irrationally or both. Lazanov method is thought to be more concerned with irrational and unconscious processes. The concept of unconsciousness; comprises numerous unconscious forms such as associating and coding.

Wednesday, November 20, 2019

Formation of the kindom of saudi arabia Essay Example | Topics and Well Written Essays - 3750 words

Formation of the kindom of saudi arabia - Essay Example These historical compliments can be but are not limited to the formation of the nation, outside influences that impacted upon this formation, foreign-policy decisions, and the way in which governance has come to be institutionalized and defined. As a function of this level of understanding, this particular analysis will first focus upon a brief history of the formation of Saudi Arabia; concentric upon leadership struggles, directional focus, conquests and subjugation. Similarly, an analysis will be made with regards to the current governmental structure that exists within Saudi Arabia. As such, a discussion of foreign-policy that utilizes the situation of how a sign with regards to how the United States and Saudi Arabia sought to accomplish different goals via the use of diplomacy and other foreign-policy instruments. One cannot begin to understand the nation of Saudi Arabia without first underscoring the importance that Abdulaziz had in creating it. Born in the year 1876 in Riyadh, now capital of Saudi Arabia, he and his family were soon forced to flee Riyadh due to the fact that a powerful tribe named the Al Rashi, a warlord from the Najd tribe, attacked and drove them to the desert town of Al-Murrah; a Bedouin tribe that exists in the very far southern deserts of Saudi Arabia. Only 15 at the time, this experience had a profound and lasting effect on Abdulaziz. Though he was not King at this time, this formative experience in the fact that he had been forced to move from his homeland provided for the impetus that he would later utilize as a means of devouring his studies. While living in the southern deserts of Saudi Arabia, he and his family were able to generate income by forming raiding parties and attacking the tribe that initially drove them from their home. These raids turned out to be rather lucrative and more and more raiders began joining the parties. Although Abdulaziz was still in his teens at this time, this understanding of the power of statecraf t and the means by which organization could affect one’s goals proves to be quite powerful. Soon thereafter, the family moved to Kuwait. It was in Kuwait that Abdulaziz’s formal education began. While there, he studied under the emir Mubarak Al-Sabah. During this time, his studies focused specifically on statecraft in the way in which nations performed, organized and how choices were made. However, perhaps the most defining moment in Abdulaziz life was in the year 1901. This was the year in which he and his half-brother, Mohammed, went back into Saudi Arabia and began organizing further raiding expeditions against Rashid and the Najd. Again, these raids proved effective, and Rashid and the tribes that were loyal to him continued to fall back under the mounting pressures that Abdulaziz placed upon them. With such an understanding, the fateful decision was made in January 1902 that Abdulaziz would attack Riyadh and take back his home. The raid was an astounding success w ith Abdulaziz only using 40 men in order to scale the walls, kill the governor, and exert new leadership over the city. This attack marks the beginning of what became known as the Third Saudi State. Although the capture of Riyadh was an important step in exhibiting control over all of Saudi Arabia, it was nonetheless only the first step. However as a

Tuesday, November 19, 2019

Time (Movie Review) Thesis Example | Topics and Well Written Essays - 1000 words

Time (Movie Review) - Thesis Example The conflict in the story begins when the woman decides to undergo plastic surgery to rekindle the waning intimacy of her relationship with her boyfriend. She instantly disappears without letting her boyfriend know and keeps her plan a secret. Her boyfriend, meanwhile, dates other women but maintains his love for his runaway girlfriend. After six months of recovering from plastic surgery, the woman resurfaces and falls in love again with his estranged boyfriend. The renewed relationship between the two is tested once more as questions of personal identity, love, and beauty emerge to the fore and devastate their once peaceful existence in time. A social commentary on plastic surgery, the film puts women as the main object of criticism in the story. Various models of women were embodied by the characters in the film. Aside from the low self-esteemed character who underwent plastic surgery, there were entertainers, a prostitute, and a confident woman who did not have identity problems. The film aims to provide a landscape of women in Korea. The landscape of these women in the film, in turn, becomes the stage on which the viewers would compare and contrast one woman character from another woman character to actual Korean women in the real world. In the film, their worth is neither measured by educational attainment nor by the ability to bear children and be good wives as possible; instead the measure of their worth depends on how well they sustain an attractive physical appearance, a beautiful face, and the ability to constantly look new, fresh, and desirable to men. â€Å"Aren’t you sick of the same body?†, as asked by one of the men in the film becomes a universal question that unconsciously haunts every Korean woman and their male partner. On a subtle level, the film seems to validate the patriarchal ideology in South Korea where men decide, in this case, what is beautiful and what is a possible candidate for a plastic surgery. But Korean women

Saturday, November 16, 2019

Current Political Dimensions and Issues of Globalization Essay Example for Free

Current Political Dimensions and Issues of Globalization Essay Globalization refers to those processes whereby geographically distant events and decisions impact to a growing degree on â€Å"local† university life. Also it can be viewed as link towards the growth of social interconnectedness across existing geographical and political boundaries. Globalization is the process of increasing interconnectedness interdependent ness of people and places as a result of improved transport and communication and information technologies that ensures countries stay together as one community. In globalization, political, economic, social, religious and cultural issues usually interplay in producing a globalize world.    The world is becoming one. most contemporary social theorists endorse the view that globalization refers to fundamental changes in the spatial and temporal contours of social existence, according to which the significance of space or territory undergoes shifts in the face of a no less dramatic acceleration in the temporal structure of crucial forms of human activity. Geographical distance is typically measured in time. (Brawley, 2002) The world’s globalization can be traced back to many decades when different countries of the world saw the need to have globalization of the economy, politics, and societies, religious through the creation of links that will ensure that there is coordination in all the aforementioned aspects that form the basis of any country. There has been great integration in the economic sector among countries in, this is what is commonly referred as economic globalization. The fast economic growth among many countries in the world can be attributed to globalization. This implies that globalization has helped reduce poverty in many developing counties. Western political theory has traditionally presupposed the existence of territorially bound communities, whose borders can be more or less neatly delineated from those of other communities. The contemporary liberal politics has it that to speak of bounded communities whose fundamental structure consists of self-sufficient schemes of cooperation for all the essential purposes of human life. (David, 1995) The current political issues in any given country are based on how to achieve and utilize globalization.   Most of the countries have resolved to form partnerships with most of the countries in the world so as to integrate their resources geared towards high production. The whole process of globalization promotes proper and easy access to the world market among the partners.   This role is played by internationals organizations that have tried to promote liberal markets. For instance business people on different continents now engage in electronic commerce; television allows people situated anywhere to observe the impact of terrible wars being waged far from the comfort of their living rooms; academics make use of the latest video conferencing equipment to organize seminars in which participants are located at disparate geographical locations; the Internet allows people to communicate instantaneously with each other notwithstanding vast geographical distances separating them. (Burchill Linklater, 1996). The whole process of globalization has its own challenges where the poor countries are not able to compete effectively in the world markets and as such the poor countries are unable to have economic growth.   There is great disparity between the developed and the developing countries and this is also inherent to the people of these countries where we have a big imbalance between the poor and the rich. Due to the process of globalization countries have a challenge on how to have political shifts that will enhance their global growth.   The political shift usually twisted towards the stakeholders of globalization. Corruption fighting is the key issue towards globalization for any country. Covering a wide range of distinct political, economic, and cultural trends, the term globalization has quickly become one of the most fashionable buzzwords of contemporary political and academic debate. In popular discourse, globalization often functions as little more than a synonym for one or more of the following phenomena: the pursuit of classical liberal free market policies in the world economy economic liberalization, the growing dominance of different forms of political, economic, and cultural life. The proliferation of new information technologies such as the Internet as well as the notion that humanity are in the anticipation of   realizing one single unified community in which major sources of social conflict have vanished through global integration. (David 1995) Ultimately globalization has been achieved through technological advancements.   It is a main challenge in the process of globalization as many counties are lagging behind in terms of technological advancements that are meant to promote fast and effective communication as well as boost high production.   The process of achieving the international development goals pays more emphasizes on reducing poverty levels in countries of the world by promoting sustainable growth by empowering the poor people. Globalization is just an opportunity that is associated with risks at the national and international level. One of the issues that has emitted from globalization is that there is freedom of movement which has made developed countries hire labour from lower cost countries this making the citizens of the country to lose their jobs.   It end result of this is that the country is focusing on its development. But globalization can not be dismissed at all but what is important is to lay good enabling structures that can enhance both an individual development as well as the country development.   This can only be done by putting in place good governance. Generally, globalization poses risks and challenges, but so far it has become a stabilizing force in Philippine politics. (Robertson, 1992) This is the only way the government could make serious headway in the fight against joblessness and poverty. There are indications that most of those uprisings in the past were supported by the business elite. They are concentrated in the banking, real estate, export, and trading. Most of these sectors now are raking in money from overseas remittances, outsourcing, and recovering exports. It means they now have a stake in the stability of the system. People in the world are encouraged to think as citizens of nations and as well global citizens if the global agenda is to be achieved.   Globalization is a force that is attaching people of countries in the world and as such globalization is the way forward. Generally, globalization is characterized by free market, new technologies internet revolution.   Due to this increased technologies little time is required to connect different geographical locations.   This has helped in reducing the issues of national boundaries as people can communicate without necessarily crossing over the national boundaries.   Many social activities can take place in the world without necessary considering the geographical location of the participants. This is done through telecommunication, digital computers, audiovisual media and this occurs everywhere in the contemporary world.   (Schorte, 1996).  Ã‚   Business is done through electronics, televisions. This has promoted both social and economic interconnectedness across the political and geographical boundaries.   This means that technical disregard to geographical boundaries is a major issue towards globalization. High speed technology plays a very crucial role in the process of globalization.   This is another issue that is hindering the achievement of globalization.   This is because most of the world’s countries and are not moving as per the dynamisms of technology thus creating slow inter border speed movements. (Scheuerman,2004) The high speed technologies minimize the significance of distance and as a result improving the interconnectedness. But in those areas where deterritorialization and social interconnectedness across national borders are especially striking, new transnational institutions (for example, cross-border referenda), along with a dramatic strengthening and further democratization of existing forms of supranational authority (in particular, the United Nations), are necessary if we are to assure that popular sovereignty remains an effective principle. Globalization guarantees sustainable competitiveness through leadership of technological improvements.   The attraction of many countries in need of investment has promoted the growth of economies in most countries that embrace globalization.   Good examples are the recent joint ventures of China with Japanese companies where the Chinese get skills directly by working the Japanese. High-speed technologies and organizational approaches are employed by transnational operating firms, the so-called â€Å"global players,† with great effectiveness. The emergence of â€Å"around-the-world, around-the-clock† financial markets, where major cross-border financial transactions are made in cyberspace at the blink of an eye, represents a familiar example of the economic face of globalization. (Mark Interline 2001) How Philippines is integrated in international economy at the global community. Philippines as far as the globalization is concerned is rated in the semi-globalize world.   The country has not achieved completely what it takes for a country to be globalized.   It is lacking integrated markets and economies with other countries.   This because it has not taken advantage of across borders integration.   Low cross borders coordination reduces the economic share activities which have an effect of reducing fast economic growth.   Philippines have now a new political shift aimed at promoting its economic growth.   One of the main issues of promoting globalization is through democratization.   This is an aspect that has been missing in Philippines, there is a tendency the country believing that poor countries should not depend on the foreign capital and for this reason the country believes in regional issues of development. Philippine is the latest country to be accepted in the global alliance nations sharing global information and economies.   The country’s software sector has greatly grown giving it advantage in global information technology.   In the year 2006, Philippines had established software innovation which aimed at creating a global centre of information.   The process of software innovation is based on good relations with other countries that have advanced technology.   This procedure has promoted individuals business within the integrated countries.   A good example is stag Philippines Company that developed an innovative online registration system for one of the domestic airlines, this is a positive movement towards globalizations. The country has moved from the traditional of doing things to the scientific and technological revolutions.   Philippines has achieved great integration in East Asia with countries such as Indonesia, Malaysia and Thailand.   This form of regional integration has promoted free market within the area hence improved economies. Globalization refers to increased possibilities for action between and among people in situations where latitudinal and longitudinal location seems immaterial to the social activity at hand. Even though geographical location remains crucial for many undertakings (for example, farming to satisfy the needs of a local market), deterritorialization manifests itself in many social spheres.. Territory in the sense of a traditional sense of a geographically identifiable location no longer constitutes the whole of â€Å"social space† in which human activity takes places. In this initial sense of the term, globalization refers to the spread of new forms of non-territorial social activity (Fred, 1998) There are great challenges for the government in trying to harmonize governance especially when there is integration of business bodies with other countries.   The process of liberalization and democratization enables the more advanced countries to take advantage of the free market.   The more developed countries use this opportunity in getting more profits which they take to their rich countries.   There is power mixing for the government as it not possible to control all the power diffusion. Each manifestation of globalization also generates distinct conflicts and dislocations. For example, there is substantial empirical evidence that cross-border flows and exchanges, as well as the emergence of directly transnational forms of production by means of which a single commodity is manufactured simultaneously in distant corners of the globe, are gaining in prominence (Castells, 1996). The whole process of Philippines involvement in international and global community is that the developed countries in term s of service provision on the onset there is un equal competition for the integrated market which the developed countries stand a better chance to exploit.   Despite the lower levels of poverty in most states, there is a general inequality in the overall income among the citizens. The inequality in Philippines occurs especially between rural and urban areas.   This has led to economic stagnation and civil instability which threatens the goal of reducing poverty by globalization.   Other places are overpopulated causing strain on the meager natural resources.   The fact that Philippines has moved global has not solved the internal disparities which threaten to increase poverty levels. The government has a great challenge of implementing certain agreements with the international community.   Such international conventions are so demanding in terms of implementation within the country.   When these legal conventions are integrated to the country they have the capacity to weaken the internal structures of the country. As an empirical matter, the decay of the domestic-foreign frontier seems highly ambivalent, since it might easily pave the way for the decay of the more attractive attributes of domestic political life: as â€Å"foreign† affairs collapse inward onto â€Å"domestic† political life, the relative lawlessness of the former potentially makes disturbing inroads onto the latter (Scheuerman, 2004) The government is also challenged by the rapidly expanding flow of goods services information and people which makes the country to be more interdependent.   This requires that the country sets global consensus to meet these challenges. Globalization-from-above is controlled by wealthy elites and driven by a hunger for more wealth and power. But there is another form of globalization in the Philippines that is made up of grassroots alliances of human rights activists, trade unions, womens organizations, and environmental coalitions and farmers’ organizations. This form of globalization however does not get as much publicity as the elite form of globalization but it is growing just as rapidly. The institutions such as the World Bank, the International Monetary Fund and transnational corporations have assisted in development and the integration of the world’s countries into the global system. The cross-boarder issues that require joint efforts have been very difficult for the Philippine government to manage.   Areas that require regional cooperation include drug supply reduction, prevention of HIV/AIDS, fight against illegal drugs.   Lack of such support has been a great set back to the government. Critics insist that local, regional, and national forms of self-government are being rapidly supplanted by insufficiently democratic forms of global governance remote from the needs of ordinary citizens, whereas their defenders describe new forms of supranational legal and political decision as indispensable forerunners to more inclusive and advanced forms of self-government. Global financial markets also challenge traditional attempts by liberal democratic nation-states to rein in the activities of bankers, spawning understandable anxieties about the growing power and influence of financial markets over democratically elected representative institutions Globalization has an effect on Philippines culture and traditions as the society’s norms and values as subject to change.   There are many ways in which the globalization may finally erode the cultural values of the people due to the volatile socialization a contribution of market liberalization and democratization. Market liberalization and the democratization has continued to adversely contributed to the deceleration in growth rate of the country because of the worsening terms of trade between the integrated countries and Philippines. There is a weak growth of exports to the developed countries but rather there are a big number of imports to the country. This means that the country spends more money to the outside countries than what it receives.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   There is a need for the developed countries to have a positive shift towards assisting the developing countries. This can be done by the removal of trade barrier to the developing countries. Philippine’s economy has been growing at 4-6% GDP due to the growth of the robust sector. Electrons and semiconductors contribute greatly to the country’s exports. There is variety of market for the Philippines products due to the globalization. A global citizen in this country is encouraged to participate actively by taking advantage of the available opportunities: outsourcing is an outcome of technological advancements. For instance, many people in the Philippines start their work at 9pm till five in the morning. Such jobs include call centers. This industry of out sources is growing at 57%per year. The Philippines has low or more open economy, a contribution of the economic reforms done as well as moving global. The linking together and expanding of social activities across borders is predicated on the possibility of relatively fast flows and movements of people, information, capital, and goods. Without these fast flows, it is difficult to see how distant events could possibly posses the influence they now enjoy. High-speed technology plays a pivotal role in the velocity of human affairs. But many other factors contribute to the overall pace and speed of social activity.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Globalization has completely changed the political and social situation of the country. The current crop of politicians believes that the future of the country depends on global connectivity and it is for this reason they support global dynamics and global competitiveness. The democratic model has been used in Philippines in the process of creating alliances with other countries. According to one influential strand within international relations theory, relations between states are fundamentally lawless. Since the achievement of justice or democracy, for example, presupposes an effective political sovereign, the lacuna of sovereignty at the global level means that justice and democracy are necessarily incomplete and probably unattainable there. In this â€Å"Realist† view of international politics, core features of the modern system of sovereign states relegate the pursuit of western political thoughts most noble normative goals primarily to the domestic arena. Other critics has that the dangers of global economy is that investors come into a particular country, present certain conditions and government often accept them without asking the people who will be affected, which is a violation of workers rights. It often happens under such deals when state companies are bought over by foreign companies, thousands of workers are laid off under so called structural adjustment program to cut the cost, while workers are pushed for longer hours and prohibited from labor unions. The whole purpose behind this way of working is exploitation of the foreign market to gain greater profit. Globalization is part of the changing world, but the way it is coming in developing countries lacks humanity. Contemporary analysts associate globalization with deterritorialization, according to which a growing variety of social activities takes place irrespective of the geographical location of participants. As Jan Aart Scholte observes, â€Å"global events can via telecommunication, digital computers, audiovisual media, rocketry and the like occur almost simultaneously anywhere and everywhere in the world. (Scholte Aart, 1996) In conclusion globalization is the way forward for Philippine’s economic and political growth. Technology is the key to the achievement of the globalization process and it is therefore very important for any country to embrace technological changes in order to be complacent with the fast changes in the world. A country that will not embrace technological changes is like lag behind in matters of development. Increased communication is panacea of any expanding economy as this promotes sharing of the international nature. Expanding free market promotes greater exchange of skills which has a net effect of improving the economy in terms of the factors maximizing the factors of production such as capital, land, entrepreneurship. Outsourcing is the contemporary form of globalization that is practiced in the contemporary Philippine and this has led to the improved social relation among the regional countries. Integration of different companies which produce similar products has enhanced the exchange of technologies by the virtue of direct contact. Finally globalization has reduced the social boundaries as well the geographical barriers and now people are staying as one big community. References Mark Randal Brawley (2002) the Politics of Globalization: Gaining Perspective, Assessing Consequences. Broadview Press. Crescenzi, Mark, and Andrew J. Interline. 2001. Time Remembered: A Dynamic Model of Interstate Interaction. International Studies Quarterly 45:409-431. Scott Burchill and Andrew Linklater, (1996). Theories of International Relations. New York: St. Martins Castells, Manuel (1996), The Rise of Network Society (Oxford: Blackwell). Dallmayr, Fred (1998), Alternative Visions: Paths in the Global Village (Lanham, Md.: Rowman Littlefield). Held, David (1995), Democracy and the Global Order: From the Modern State to Cosmopolitan Governance (Stanford: Stanford University Press). Robertson, R. (1992), Globalization: Social Theory and Global Culture, (London: Sage). Scheuerman, William E. (2004), Liberal Democracy and the Social Acceleration of Time (Baltimore: Johns Hopkins Press, 2004). Scholte, Jan Aart (2000), Globalization: A Critical Introduction (New York: St. Martins).

Thursday, November 14, 2019

The Human Brain Essay -- Health, Diseases, Brain Damage

The human brain is a big, intricate—yet delicate, structure in the human body. It is the key structure in cognitive function. Any damage to the brain does not only â€Å"erase† memories but also may â€Å"deceive† the brain to erroneously remember a new object as being familiar (2010). The innovative researchers at Cambridge University investigated this phenomenon in their research on The Paradoxial False Memory for Objects after Brain Damage. The publication began by stating the widely acceptable premise that medial temporal lobe damage results in the inability to remember new experiences soon after they are learned. They indicated that the general belief is that this occurs because the ability to remember such information becomes compromised after a short period of time. They therefore deduced based on this premise that such information or experiences are either lost or become inaccessible to the extent that when such experiences are presented and re-experienced, they appear as if they are new or never have been learned. They therefore set out to explore this premise by using the generally used model of memory impairment, the â€Å"the standard object recognition memory model.† According to James Hampton, a well-renowned Professor of Cognitive Psychology at City University London, â€Å"recognition is the process of matching a perceptual representation of the stimulus item [into] stored representations of previously [exposed] stimuli† (2003). This stored information is known as structural representations based on the visual-spatial nature of the retained information (Moss and Hampton, 2003). â€Å"Object recognition memory is the ability to discriminate the familiarity of previously encountered objects† (Gaskins et al., 2009). The standard object ... ...indings from the simulation were valid because animals that suffered damage to the perirhinal cortex saw novel objects as familiar. Based on the support of these simulations and their laboratory findings, I agree with the notion â€Å"that object recognition memory impairments does not result from damage to the memory system. Rather brain damage that results in such impairments only compromises only a [precise] type of complex stimulus representation† (McTighe et al., 2010). Such may be the case of individuals with cortical brain damage such amnesia and Alzheimer’s disease based the combination of perirhinal lesions and object recognition impairments similar to the findings in this research. However in order to evaluation between and the paradoxical phenomenon, more research is needed and further representation-hierarchical simulation testing must be performed on humans. The Human Brain Essay -- Health, Diseases, Brain Damage The human brain is a big, intricate—yet delicate, structure in the human body. It is the key structure in cognitive function. Any damage to the brain does not only â€Å"erase† memories but also may â€Å"deceive† the brain to erroneously remember a new object as being familiar (2010). The innovative researchers at Cambridge University investigated this phenomenon in their research on The Paradoxial False Memory for Objects after Brain Damage. The publication began by stating the widely acceptable premise that medial temporal lobe damage results in the inability to remember new experiences soon after they are learned. They indicated that the general belief is that this occurs because the ability to remember such information becomes compromised after a short period of time. They therefore deduced based on this premise that such information or experiences are either lost or become inaccessible to the extent that when such experiences are presented and re-experienced, they appear as if they are new or never have been learned. They therefore set out to explore this premise by using the generally used model of memory impairment, the â€Å"the standard object recognition memory model.† According to James Hampton, a well-renowned Professor of Cognitive Psychology at City University London, â€Å"recognition is the process of matching a perceptual representation of the stimulus item [into] stored representations of previously [exposed] stimuli† (2003). This stored information is known as structural representations based on the visual-spatial nature of the retained information (Moss and Hampton, 2003). â€Å"Object recognition memory is the ability to discriminate the familiarity of previously encountered objects† (Gaskins et al., 2009). The standard object ... ...indings from the simulation were valid because animals that suffered damage to the perirhinal cortex saw novel objects as familiar. Based on the support of these simulations and their laboratory findings, I agree with the notion â€Å"that object recognition memory impairments does not result from damage to the memory system. Rather brain damage that results in such impairments only compromises only a [precise] type of complex stimulus representation† (McTighe et al., 2010). Such may be the case of individuals with cortical brain damage such amnesia and Alzheimer’s disease based the combination of perirhinal lesions and object recognition impairments similar to the findings in this research. However in order to evaluation between and the paradoxical phenomenon, more research is needed and further representation-hierarchical simulation testing must be performed on humans.

Monday, November 11, 2019

10 Critical Decision areas of operation management Essay

I. Goods and service design. According to Henzer (2004), design of goods and design defines much of the transformation process. The factors of cost, quality and human resources must be made during the stage. Operation management of product and services is also different because due to different characteristic and tangible / intangible feature. II. Quality. Customer has a very high quality standard nowadays and operation management decision in quality must be clear and strict for its members to understand and comply. It must set a quality, standard and operating procedure to meet customers’ high expectation. III. Process and capacity design. Manufacturing of physical products may have higher importance on process and capacity design than services operation. Operation management (product) should decide what process it, what type of technology and to what extent, human resources, quality and maintenance that determines its basic cost structure. Services operation decision on this area is much simpler and it can determine by customers who directly involved in the process. For example, customer will ask tailor to design specific fashion clothes. Capacity design issue is critical for services because it will try to reduce waiting time and avoid lost of sales due to insufficient capacity. For manufacturing capacity design is based on firms financial capability, forecast for future and market demand. IV. Location can be an area for operation management to decide and with globalization of business, operation managers too must think global. For physical goods, location selection can be determined by pools of qualified human resources, technology, raw material, access to market and government policy. For services as it is direct to customers, the location is determined by market accessibility or near to customer as possible. V. Layout design. Material flow, process selection technology used, capacity needs, workers needs, inventory requirement, and capital will influence the  decision for layout design. For services such as hotels, beside capacity needs layout also will enhance its attributes and features to the customers. VI. Human Resources and Job Design – Employees is the integral part in the total system design. Operation management must set a policy to set labor standards to ease transition of skills, improvement of knowledge, skills and abilities (KSA), build a balance work and life quality in an effective cost target. For services one extra area operation management should touch, which is customers relationship that they are dealing directly. VII. Supply Chain Management – Decisions that have to take place of what to produce, what material to buy, from where, how is the cost and how is the delivery from supplier to the final end customers in on-time delivery and minimum cost possible. It is more critical in production of goods than services. VIII. Inventory – Decisions on how and where the inventory level to keep long term customers satisfaction, suppliers, material availability for not to disrupt the production, human resources needed for this purpose and important the holding cost from financial perspective. Goods production are more concern because manufacturer may kept raw material, in progress work order and final goods while services is not critical as it is directly produce and consume simultaneously. IX. Scheduling – Efficient way of allocation, control and management of materials, capital goods and human resources to efficiently produce the final goods from the input available. Schedules are more formal in goods production with short, medium and long term planning to accommodate customers demand. For services the demand is more direct and volatile and often concern on human resources and KSA availability to meet current customers needs. X. Maintenance – Decision must be made regarding the desired level of reliability, stability and systems must be established by management to maintain that reliability and stability.

Saturday, November 9, 2019

Human Resource Plan Essay

Abstract Planning is important in our everyday life. Similarly planning in Human Resource (HR) is significant for an organization wishing to be successful. It is vital for attaining competitive edge in the market. Mostly top management fails to use HR Department more than as administrative support because they don’t realize its importance in managing the most crucial asset of the organization i. e. Human Resource (Rothwell, W. J and Kazanas, H. C. , 2002). In this paper an HR Plan has been formulated for getting a practical view of Human Resource Planning. Super Mart is an American company dealing in chain of departmental stores. Founded in 1972, it is the largest private employer and grocery retailer in United States. It owns 20% of the market share. It is functional across globe in U. K, Mexico, Argentina, China, South America, Puerto Rico, Brazil, Canada, Japan, Germany and South Korea. The company’s main competitor includes American Superstore, Sellers and Canada’s PurchaseKo (Frank, 2006). Super Mart has developed a frugal culture. The company’s aim has been to keep the prices low and also maintain the cutting-edge technology, a frugal corporate culture and a drive to make suppliers sell merchandise at cheaper prices. The employees are expected to keep the expenses at bare minimum. This shows in the meager salary and health facilities provided to the employees. The culture is present at the Headquarter also which is situated in a suburban location of Arkansas rather than New York. Its executives use coaches and don’t drive limousines and share hotel rooms. They come early, go late and work half day on Saturdays. The company’s main aim is delivering to customers at low cost which shows in its work culture as well (Wilbert, n. d. ). For its internal communication Super Mart has recruited 300 HR personnel, whose job is to communicate the business objectives and growth opportunities to the employees. There also has been an integration of human resource practices with all business strategies for ensuring that all the employees are moving in same direction. An Ethics hotline has been developed where all the ethical issues are reported and promptly investigated (Wal-Mart’s new Communication Plan, 2007). The company has also updated its website to include all issues and controversies. The answer to the question as to why an employee will choose Super Mart as its employer lies in its brand value. Super Mart has 270 stores across America and has global presence. Its initiative in health care and employee benefits are gaining praise. Super Mart has realized that it is successful if its employees are happy, especially as it belongs to service sector, which spells good news for the employees. Recruitment and Selection Recruitment is an important aspect for planning manpower. The recruitment process has been divided into four stages i. e. search plan, selection techniques, timetable and recruitment budget (Human resource Planning, 2006) Search Plan: For attracting the potential employees, media tools like advertising, visits at university and job exhibition are planned. This process is carried on for a period of one month. Selection Techniques: First job specification is designed for a particular position, say for front office employee. Educational Qualification: 10+2 or Graduate Age limit: 25- 30 Qualities: Good communication skills, ready to work in shifts, adaptable to situations, customer friendly and persuasive and eye for detail. On the basis of the above specifications, candidates are shot listed and interviewed. The successful candidates are recommended and unsuccessful candidates are thanked and send back. The selection decision is detained with the area manager only. Timetable: The recruitment and selection process is spread over for four months, from January to April. The recruitment budget covering the advertisement, assessment of applications, interviews and reference checks of employees have been estimated around 2lac. The job description and interview questions have been provided in the appendix. Compensation and Benefits For determining compensation for various posts’ salary, survey is carried out. For making correct comparison, not only matching the job title but matching job duties and responsibilities is also essential. Salary is decided by considering labor market characteristics and cost of living (HR Planning, n. . ). Going by the example taken in this paper for fixing salary for front office employees, their job description is reviewed. Also other components apart from basic salary like traveling allowance and extra pay for overtime have been included (see appendix). Performance Management The performance appraisal of employees is an essential process to keep the employees in check as well as monitor the quality of work. It also provides avenues for development based on feedback and lacunae are identified. Here, as the employees in consideration are front office employees, a simple tool for performance management is selected as the Rating Scale Method. As only basic qualities are expected out of the employees and no technical or high expertises are required, a simple technique like Rating Scale is preferable. In rating scale, the appraiser is asked to rate individual employee on the basis of qualities identified like communication skills, customer feedback, product knowledge, attitude etc. (Sturo, J. , 2006). Employees are ranked on the basis of points assigned to them. Training Program Training is an integral part of HR activity. It is provided not only to new employees but also to the existing employees due to the technological changes or change in ways of marketing or introduction of any new methodology at work. The front office workers are provided training in communication and product knowledge. Certain level of computer education is also given for handling the billing job. The training period lasts for two weeks which includes lectures and simulation program. At the end of the training program, new employees are kept on a probation period of one month where their performance is monitored. Employees showing lack of any learning or scope of improvement are discharged. Retention Program A lot of revenue and time is devoted towards recruiting and selecting people for any position. The story doesn’t end here. The new employee is trained and becomes productive only after a month or so. This adds further to the expenses. Thus, loosing an employee in a short duration after putting so much of money into his/her development becomes uneconomical. This spells more damage for service sector companies because being intangible form of product customers symbolize their experience as equivalent to the standard of service offered. And front office staff is the key to this satisfaction in a big way. Thus, in order to retain the employees, various retention techniques should be adopted, for example incentives for being rated at the top of performance appraisal for consecutive three times, awards for most punctual and well dressed employees, having a star system where employees are given a star badge if he/she has received five positive customer feedback in a month etc. Super Mart is an American Company with global presence. But throughout the years, it is having an approach of ignoring the human resource development by following a frugal system. But with the changing time, it has realized that the best way to succeed is to have happy employees. Keeping this in mind, it has come up with an HR plan which covers areas of recruitment, compensation and benefits, training, performance benefits and retention programs. Hope it will bring smiles for the employees as well as the company in the future. Appendix Job Description: Working hour is 24/7 divided in shifts of 6 hours on a rotational basis. Employees should have good communication skills and identifying products Employees will be expected to deal with customers with patience Assisting customer with making right purchase choice and managing customer flow. Politeness and earnestness to help are other desirable qualities. Interview Questions: Tell me something about yourself? Have you ever lost your cool? When and why? Describe any random product’s features. Compensation Description Basic salary: 9000 Conveyance: 500 For overtime: 500 Total salary: 10,000 Rating Scale for Front Office Employee